GLP-1 Weight Loss Predictor

Q: How much weight can you lose on Ozempic in 3 months?

Clinical trials show that most people on semaglutide lose approximately 5-8% of their body weight in the first 3 months. For a 240-pound person, that is roughly 12-19 lbs.

How Much Weight Can You Actually Lose on GLP-1 Medications?

GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) consistently deliver 10–22% total body weight loss in clinical settings. This calculator gives you a realistic estimate based on trial data from the STEP and SURMOUNT programs.

Semaglutide (Ozempic & Wegovy) Weight Loss Expectations

The STEP 1 trial showed an average of 14.9% body weight loss over 68 weeks at the 2.4mg dose. Ozempic at lower doses produces roughly 12–14% on average. See our complete Ozempic guide or use the Drug Comparison Tool.

Tirzepatide (Mounjaro & Zepbound) — Stronger Results

The SURMOUNT-1 trial showed an average 22.5% body weight loss at 15mg. Read our Mounjaro guide or the Semaglutide vs Tirzepatide comparison.

Factors That Influence Your Results

Dosage escalation: Higher doses generally produce more weight loss.
Diet quality: See the Protein Calculator.
Exercise: Resistance training reduces muscle loss. See our Preventing Muscle Loss guide.
Adherence: Missing doses reduces cumulative efficacy.

Understanding the Weight Loss Plateau

Use the Plateau Calculator to estimate when a plateau might occur and what factors can help break through it.

Frequently Asked Questions

How much weight can you lose on Ozempic in 3 months?

Clinical trials show most people on semaglutide lose approximately 5–8% of body weight in the first 12 weeks. For a 240-pound person, that's roughly 12–19 lbs.

Does Mounjaro cause more weight loss than Ozempic?

Yes, on average. Tirzepatide produces about 20–22% total body weight loss vs approximately 15–17% for semaglutide 2.4mg. Use our Drug Comparison Tool for a detailed head-to-head.

When does weight loss plateau on GLP-1 medications?

A true plateau typically occurs around months 9–12 for semaglutide and months 10–14 for tirzepatide. Use our Plateau Calculator for a personalized estimate.