Can I slow down my GLP-1 dose escalation?

Yes. If you're experiencing significant nausea, vomiting, or other side effects, your doctor may recommend staying at your current dose longer before increasing. Some patients take 6–8 weeks at each step rather than the standard 4. Slower escalation often reduces side effects without significantly impacting long-term weight loss outcomes.

What day of the week should I inject my GLP-1 medication?

You can inject on any day of the week, but you should aim for the same day each week. Many people choose a day they can easily remember, such as Monday or Sunday. The key is consistency — injecting on the same day maintains steady drug levels in your system.

GLP-1 Dose Schedule Tool — Ozempic, Wegovy, Mounjaro, Zepbound

GLP-1 Dose Escalation: Why Titration Matters

All GLP-1 receptor agonist medications use a gradual dose escalation protocol called titration. Starting low and increasing slowly is the single most effective way to minimize nausea, vomiting, and other GI side effects that cause many people to discontinue treatment prematurely. See our Side Effect Timeline to understand when symptoms typically peak and resolve.

Ozempic Dosing Schedule

Ozempic Standard Titration

Weeks	Dose	Phase	Notes
1–4	0.25 mg	Initiation	Starting dose, not therapeutic
5–8+	0.5 mg	Maintenance	Minimum effective dose
13+	1 mg	Escalation	If more control needed
17+	2 mg	Maximum	Maximum approved dose

Wegovy Dosing Schedule

Wegovy Standard Titration

Weeks	Dose	Phase
1–4	0.25 mg weekly	Initiation
5–8	0.5 mg weekly	Step 2
9–12	1.0 mg weekly	Step 3
13–16	1.7 mg weekly	Step 4
17+	2.4 mg weekly	Maintenance

Mounjaro & Zepbound Dosing Schedule

Mounjaro / Zepbound Standard Titration

Weeks	Dose	Phase
1–4	2.5 mg weekly	Initiation
5–8	5 mg weekly	Step 2
9–12	7.5 mg weekly	Step 3
13–16	10 mg weekly	Step 4
17–20	12.5 mg weekly	Step 5
21+	15 mg weekly	Maximum

Tips for Staying on Schedule

Same day, every week. Pick a day that's easy to remember.
Set a phone reminder. A weekly alarm 30 minutes before your planned injection time helps build the habit.
Don't rush escalation. If you're experiencing significant nausea, stay at your current dose an extra 2–4 weeks before increasing.
Log your doses. Use our Weight Tracker to log both your injections and weekly weight together.
Know what to do if you miss a dose. Use the Missed Dose Tool for specific guidance.

Frequently Asked Questions

What is the Ozempic dose escalation schedule?

Ozempic starts at 0.25mg weekly for 4 weeks (initiation only, not therapeutic), then 0.5mg for at least 4 weeks. If more control is needed it increases to 1mg, then up to 2mg maximum — each step requiring at least 4 weeks. See our full Ozempic guide.

What is the Wegovy dosing schedule?

Wegovy uses a 5-step escalation: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg maintenance, each step lasting 4 weeks. Full escalation takes about 16 weeks. See our Wegovy guide.

What is the Mounjaro titration schedule?

Mounjaro starts at 2.5mg weekly for 4 weeks, then 5mg for 4 weeks. After that the dose can increase by 2.5mg every 4 weeks up to 15mg maximum. Many patients find 10mg or 12.5mg to be their optimal dose. Read the full Mounjaro guide.

Can I slow down my dose escalation?

Yes — and many doctors recommend it. Staying at each dose for 6–8 weeks instead of 4 often dramatically reduces nausea without meaningfully affecting long-term outcomes. Select "Slower titration" above to generate that calendar.

What happens if I miss a GLP-1 injection?

If 5 days or fewer have passed since your scheduled injection, take the missed dose as soon as you remember. If more than 5 days have passed, skip it and resume your normal weekly schedule. Use our Missed Dose Tool for step-by-step guidance.

What day of the week should I inject?

Any day works — the key is the same day every week. Many people avoid Fridays or Saturdays so first-dose nausea doesn't interfere with weekend plans. Sunday morning or Monday evening are popular choices.

GLP-1 Dose Schedule Tool